Thomas Joice, Dong Zeyuan, Dehaen Wim, Smet Mario
Molecular Design and Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan, 200F, 3001 Leuven (Heverlee), Belgium.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, P. R. China.
Macromol Rapid Commun. 2012 Dec 21;33(24):2127-32. doi: 10.1002/marc.201200519. Epub 2012 Sep 21.
A series of novel hyperbranched polyselenides and polytellurides with multiple catalytic sites at the branching units has been synthesized via the polycondensation of A2 + B3 monomers. The GPx-like activities of these polymer mimics were assessed and it was found that the polytellurides showed higher GPx-like activities than the corresponding polyselenides. Interestingly, the polymers with higher molecular weights and degree of branching (DB) showed higher GPx-like activities than the analogous lower molecular weight polymer. The enhancement in the catalytical activity of the hyperbranched polymers with increasing molecular weight affirmed the importance of the incorporation of multiple catalytic groups in the macromolecule which increases the local concentration of catalytic sites.
通过A2 + B3单体的缩聚反应，合成了一系列在支化单元处具有多个催化位点的新型超支化聚硒化物和聚碲化物。评估了这些聚合物模拟物的类谷胱甘肽过氧化物酶（GPx）活性，发现聚碲化物显示出比相应的聚硒化物更高的类GPx活性。有趣的是，具有较高分子量和支化度（DB）的聚合物比类似的低分子量聚合物显示出更高的类GPx活性。超支化聚合物的催化活性随着分子量的增加而增强，这证实了在大分子中引入多个催化基团的重要性，这增加了催化位点的局部浓度。
