Mishra Abhay Prakash, Kumar Rajesh, Harilal Seetha, Nigam Manisha, Datta Deepanjan, Singh Sudarshan, Waranuch Neti, Chittasupho Chuda
Cosmetics and Natural Products Research Centre, Department of Pharmaceutical Technology, Naresuan University, Phitsanulok, 65000, Thailand.
Faculty of Pharmaceutical Sciences, Kerala University of Health Sciences, Kerala, 680596, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan;398(1):497-532. doi: 10.1007/s00210-024-03469-x. Epub 2024 Oct 31.
Advancements in therapeutic strategies and combinatorial approaches for cancer management have led to the majority of cancers in the initial stages to be regarded as treatable and curable. However, certain high-grade cancers in the initial stages are still regarded as chronic and difficult to manage, requiring novel therapeutic strategies. In this era of targeted and precision therapy, novel strategies for targeted delivery of drug and synergistic therapies, integrating nanotherapeutics, polymeric materials, and modulation of the tumor microenvironment are being developed. One such strategy is the study and utilization of smart-nano biomedicine, which refers to stimuli-responsive polymeric materials integrated with the anti-cancer drug that can modulate the reactive oxygen species (ROS) in the tumor microenvironment or can be ROS responsive for the mitigation as well as management of various cancers. The article explores in detail the ROS, its types, and sources; the antioxidant system, including scavengers and their role in cancer; the ROS-responsive targeted polymeric materials, including synergistic therapies for the treatment of cancer via modulating the ROS in the tumor microenvironment, involving therapeutic strategies promoting cancer cell death; and the current landscape and future prospects.
癌症治疗策略和联合治疗方法的进展已使大多数早期癌症被视为可治疗和可治愈的。然而，某些早期的高级别癌症仍被视为慢性病且难以管理，需要新的治疗策略。在这个靶向和精准治疗的时代，正在开发用于药物靶向递送和协同治疗的新策略，这些策略整合了纳米治疗学、聚合物材料以及对肿瘤微环境的调节。其中一种策略是智能纳米生物医学的研究与应用，它是指与抗癌药物相结合的刺激响应性聚合物材料，这种材料可以调节肿瘤微环境中的活性氧（ROS），或者对ROS有响应，用于缓解和管理各种癌症。本文详细探讨了ROS、其类型和来源；抗氧化系统，包括清除剂及其在癌症中的作用；ROS响应性靶向聚合物材料，包括通过调节肿瘤微环境中的ROS来治疗癌症的协同治疗方法，涉及促进癌细胞死亡的治疗策略；以及当前的现状和未来前景。
