碳纳米管通过上调髓源抑制细胞增强肺癌的转移生长。
Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.
机构信息
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA.
出版信息
Small. 2013 May 27;9(9-10):1691-5. doi: 10.1002/smll.201201470. Epub 2012 Sep 20.
Abstract
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
摘要
单壁碳纳米管（SWCNT）促进 C57BL6/J 小鼠Lewis 肺癌的转移建立和生长。这种作用是通过增加髓源抑制细胞（MDSC）的局部和全身积累来介导的，因为它们的耗竭消除了体内的促肿瘤活性。这些数据对于设计具有能够耗竭或功能抑制 MDSC 的模块的新型治疗学平台非常重要，以确保在肿瘤微环境中进行有效的免疫监视。
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