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本文引用的文献

1
Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes.多壁碳纳米管的胸膜穿透分布和持久性。
Part Fibre Toxicol. 2010 Oct 4;7:28. doi: 10.1186/1743-8977-7-28.
2
Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts.分散的单壁碳纳米管对人肺成纤维细胞的直接致纤维作用。
J Toxicol Environ Health A. 2010;73(5):410-22. doi: 10.1080/15287390903486550.
3
Induction of aneuploidy by single-walled carbon nanotubes.单壁碳纳米管诱导非整倍体
Environ Mol Mutagen. 2009 Oct;50(8):708-17. doi: 10.1002/em.20529.
4
Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.一氧化氮介导的 bcl-2 稳定促进人肺上皮细胞恶性转化。
Am J Respir Cell Mol Biol. 2010 May;42(5):578-85. doi: 10.1165/rcmb.2009-0094OC. Epub 2009 Jun 25.
5
Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?间皮瘤：石棉和碳纳米管是否存在同样的健康风险？
Part Fibre Toxicol. 2009 Jun 12;6:16. doi: 10.1186/1743-8977-6-16.
6
Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro.纳米材料的遗传毒性：碳纳米管和石墨纳米纤维在体外诱导人支气管上皮细胞的DNA损伤和微核形成。
Toxicol Lett. 2009 May 8;186(3):166-73. doi: 10.1016/j.toxlet.2008.11.019. Epub 2008 Dec 7.
7
Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?碳纳米管的肺毒性机制及医学应用：双面雅努斯？
Pharmacol Ther. 2009 Feb;121(2):192-204. doi: 10.1016/j.pharmthera.2008.10.009. Epub 2008 Dec 6.
8
Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells.未加工的单壁碳纳米管在正常和恶性人间皮细胞中诱导氧化应激并激活丝裂原活化蛋白激酶、活化蛋白-1、核因子κB和蛋白激酶B。
Environ Health Perspect. 2008 Sep;116(9):1211-7. doi: 10.1289/ehp.10924.
9
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study.在一项初步研究中，引入小鼠腹腔的碳纳米管显示出类似石棉的致病性。
Nat Nanotechnol. 2008 Jul;3(7):423-8. doi: 10.1038/nnano.2008.111. Epub 2008 May 20.
10
Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.通过腹腔内应用多壁碳纳米管在p53基因杂合小鼠中诱发间皮瘤。
J Toxicol Sci. 2008 Feb;33(1):105-16. doi: 10.2131/jts.33.105.

碳纳米管诱导人肺上皮细胞恶性转化和肿瘤发生。

Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.

机构信息

Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States.

出版信息

Nano Lett. 2011 Jul 13;11(7):2796-803. doi: 10.1021/nl2011214. Epub 2011 Jun 9.

DOI:10.1021/nl2011214
PMID:21657258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135732/
Abstract

Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.

摘要

碳纳米管的致癌性是一个主要关注点，但由于缺乏实验模型，尚未得到很好的解决。在这里，我们表明，慢性暴露于单壁碳纳米管会导致人肺上皮细胞的恶性转化。转化细胞在小鼠中诱导肿瘤发生，并表现出类似于癌细胞的抗凋亡表型。这项研究为碳纳米管诱导的致癌性提供了新的证据，并表明了 p53 在这一过程中的潜在作用。