碳纳米管诱导人肺上皮细胞恶性转化和肿瘤发生。
Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
机构信息
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States.
出版信息
Nano Lett. 2011 Jul 13;11(7):2796-803. doi: 10.1021/nl2011214. Epub 2011 Jun 9.
Abstract
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process.
摘要
碳纳米管的致癌性是一个主要关注点，但由于缺乏实验模型，尚未得到很好的解决。在这里，我们表明，慢性暴露于单壁碳纳米管会导致人肺上皮细胞的恶性转化。转化细胞在小鼠中诱导肿瘤发生，并表现出类似于癌细胞的抗凋亡表型。这项研究为碳纳米管诱导的致癌性提供了新的证据，并表明了 p53 在这一过程中的潜在作用。
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