Besirli Kazim, Aydemir Birsen, Arslan Caner, Kiziler Ali Riza, Canturk Emir, Kayhan Bekir
Cardiovascular Surgery Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Rev Bras Cir Cardiovasc. 2012 Apr-Jun;27(2):260-6.
Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters. It is an antioxidant that increases endothelial-derived vasodilator substance secretion, there are none that analyze its effects during the postoperative period of patients undergoing myocardial revascularization.
We aimed to determine the effects of calcium dobesilate on hemorheological parameters, such as reduced glutathione and malondialdehyde in patients with ischemic heart disease undergoing myocardial revascularization in the postoperative period.
One hundred and thirty-four patients operated for coronary heart disease were included in this study. Hemorheological, oxidant and antioxidant parameters were measured two days after surgery and after a period of treatment with calcium dobesilate. Then, 500 mg of calcium dobesilate was given twice a day to one group of 68 patients for three months. The control group was composed of 66 patients who did not receive this medication.
The increase in the erythrocyte deformability index was found to be significant compared with both the pretreatment values and with the 1st and 2nd values of the control group after calcium dobesilate administration, whereas there were no significant changes in blood viscosity, glutathione (GSH) or malondialdehyde (MDA) values after the calcium dobesilate administration. The same improvement in the CCS class was observed in patients regardless of they received the calcium dobesilate treatment.
In the present investigation, the same improvement in the CCS class was observed in patients regardless of they received the calcium dobesilate treatment. Improvements with calcium dobesilate were statistically significant only in the increase in erythrocyte flexibility.
羟苯磺酸钙是一种血管保护剂，对血液流变学参数有积极影响。它是一种抗氧化剂，可增加内皮源性血管舒张物质的分泌，目前尚无分析其在心肌血运重建术后患者中的作用的研究。
我们旨在确定羟苯磺酸钙对缺血性心脏病患者心肌血运重建术后血液流变学参数的影响，如还原型谷胱甘肽和丙二醛。
本研究纳入了134例接受冠心病手术的患者。在术后两天以及接受羟苯磺酸钙治疗一段时间后，测量血液流变学、氧化和抗氧化参数。然后，一组68例患者每天两次服用500毫克羟苯磺酸钙，持续三个月。对照组由66例未接受此药物治疗的患者组成。
与治疗前值以及对照组在给予羟苯磺酸钙后的第1和第2次测量值相比，红细胞变形性指数的增加具有显著意义，而给予羟苯磺酸钙后血液粘度、谷胱甘肽（GSH）或丙二醛（MDA）值无显著变化。无论患者是否接受羟苯磺酸钙治疗，纽约心脏病协会（CCS）分级均有相同程度的改善。
在本研究中，无论患者是否接受羟苯磺酸钙治疗，CCS分级均有相同程度的改善。羟苯磺酸钙仅在增加红细胞柔韧性方面的改善具有统计学意义。
