Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran.
J Sep Sci. 2012 Sep;35(18):2476-83. doi: 10.1002/jssc.201101099.
In the present work the combination of two liquid-phase microextraction techniques involving dispersive liquid-liquid microextraction and single-drop microextraction as a new pre-concentration technique is developed for the separation and determination of acidic non-steroidal anti-inflammatory pharmaceutical compounds, namely, naproxen, diclofenac, and ibuprofen, in water samples using high-performance liquid chromatography ultra violet-detection. The extraction conditions were optimized and, under the optimal conditions, the method showed good linearity range of 0.1-1000 μg L(-1) (R > 0.9990), acceptable reproducibilities (relative standard deviation% = 4.5-8.8%), low limits of detection (0.03-0.2 μg L(-1) ), and satisfactory relative recoveries. The developed method was applied for the determination of anti-inflammatory drugs in river and waste water samples.
在本工作中，开发了一种将两种液相微萃取技术（包括分散液液微萃取和单滴微萃取）结合作为一种新的预浓缩技术，用于分离和测定水样中的酸性非甾体抗炎药物化合物，即萘普生、双氯芬酸和布洛芬，采用高效液相色谱紫外检测法。优化了萃取条件，在最佳条件下，该方法显示出良好的线性范围为 0.1-1000 μg L(-1)（R > 0.9990），可接受的重现性（相对标准偏差% = 4.5-8.8%），低检测限（0.03-0.2 μg L(-1)）和令人满意的相对回收率。该方法已应用于河流和废水样品中抗炎药物的测定。
