应用多普勒光学相干断层扫描技术测量单一脉络膜血管血流。
An approach to measure blood flow in single choroidal vessel using Doppler optical coherence tomography.
机构信息
Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Japan.
出版信息
Invest Ophthalmol Vis Sci. 2012 Oct 1;53(11):7137-41. doi: 10.1167/iovs.12-10666.
PURPOSE
To evaluate the absolute blood flow rate in a single choroidal vessel using Doppler optical coherence tomography (OCT).
METHODS
Three choroidal vessels were selected in the right eye of three normal subjects, and were measured with Doppler OCT at a 1020-nm probe wavelength. The pulsatile change of the blood flow was obtained from synchronized measurement of Doppler OCT and plethysmography. Absolute blood flow rates in choroidal vessels were calculated from Doppler OCT volume data.
RESULTS
The cyclic change of the blood flow was quantitatively obtained. Absolute blood flow velocities and blood flow rates at peak systole [mean (SD)] were 46.9 (12.5) mm/s and 5.9 (3.6) μL/min, respectively. The coefficient of variation of three sets of measurements [mean (SD)] was 9.3 (4.9%).
CONCLUSIONS
Doppler OCT and plethysmography provided an accurate quantitative assessment of the blood flow in choroidal vessels. This measurement technique could prove valuable to the study of choroidal blood flow in normal and pathologic conditions.
目的
利用多普勒光学相干断层扫描（OCT）评估单个脉络膜血管的绝对血流速率。
方法
在 3 名正常受试者的右眼选择 3 条脉络膜血管，在 1020nm 探测波长下用多普勒 OCT 进行测量。通过多普勒 OCT 和容积描记法的同步测量获得血流的搏动变化。从多普勒 OCT 容积数据计算脉络膜血管的绝对血流速率。
结果
定量获得了血流的周期性变化。峰值收缩期的平均（SD）绝对血流速度和血流速率分别为 46.9（12.5）mm/s 和 5.9（3.6）μL/min。3 组测量的变异系数（SD）为 9.3（4.9%）。
结论
多普勒 OCT 和容积描记法为脉络膜血管的血流提供了准确的定量评估。这种测量技术可能对研究正常和病理条件下的脉络膜血流具有重要价值。
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