一氧化氮对损伤诱导的神经发生的调节作用。
Regulation of injury-induced neurogenesis by nitric oxide.
机构信息
Centre for Neuroscience and Cell Biology, Neuroendocrinology and Neurogenesis Group, University of Coimbra, Coimbra, Portugal.
出版信息
Stem Cells Int. 2012;2012:895659. doi: 10.1155/2012/895659. Epub 2012 Sep 10.
Abstract
The finding that neural stem cells (NSCs) are able to divide, migrate, and differentiate into several cellular types in the adult brain raised a new hope for restorative neurology. Nitric oxide (NO), a pleiotropic signaling molecule in the central nervous system (CNS), has been described to be able to modulate neurogenesis, acting as a pro- or antineurogenic agent. Some authors suggest that NO is a physiological inhibitor of neurogenesis, while others described NO to favor neurogenesis, particularly under inflammatory conditions. Thus, targeting the NO system may be a powerful strategy to control the formation of new neurons. However, the exact mechanisms by which NO regulates neural proliferation and differentiation are not yet completely clarified. In this paper we will discuss the potential interest of the modulation of the NO system for the treatment of neurodegenerative diseases or other pathological conditions that may affect the CNS.
摘要
研究发现，神经干细胞（NSCs）能够在成年大脑中分裂、迁移并分化为多种细胞类型，这为修复神经科学带来了新的希望。一氧化氮（NO）是中枢神经系统（CNS）中的一种多效信号分子，已被描述为能够调节神经发生，作为一种促进或抗神经发生的物质。一些作者认为 NO 是神经发生的生理性抑制剂，而另一些作者则描述 NO 有利于神经发生，特别是在炎症条件下。因此，靶向 NO 系统可能是控制新神经元形成的有力策略。然而，NO 调节神经增殖和分化的确切机制尚未完全阐明。在本文中，我们将讨论调节 NO 系统对治疗神经退行性疾病或其他可能影响中枢神经系统的病理状况的潜在意义。
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