Lee Hwayoung, Kang Sung Wook, Jeong Hyeonjung, Kwon Jun-Tack, Kim Young Ock, Kim Hak-Jae
Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan, Korea.
Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, USA.
Clin Psychopharmacol Neurosci. 2021 Nov 30;19(4):618-627. doi: 10.9758/cpn.2021.19.4.618.
The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression of Cng channel, cyclic nucleotide-gated channel subunit beta 1 (Cngb1) exhibited any relationship with the pathophysiology of schizophrenia in an animal model and whether genetic polymorphisms of the human gene were associated with the progression of schizophrenia in a Korean population.
We investigated whether Cngb1 expression was related to psychiatric disorders in a mouse model of schizophrenia induced by maternal immune activation. A case-control study was conducted of 275 schizophrenia patients and 410 controls with single-nucleotide polymorphisms (SNPs) in the 5'-near region of .
Cngb1 expression was decreased in the prefrontal cortex in the mouse model. Furthermore, the genotype frequency of a SNP (rs3756314) of was associated with the risk of schizophrenia.
Our results suggest that might be associated with schizophrenia susceptibility and maternal immune activation. Consequently, it is hypothesized that may be involved in the pathophysiology of schizophrenia.
环核苷酸门控通道（Cng）通过响应环核苷酸浓度变化调节钙水平，从而调节脑神经元中的突触效能。本研究调查了在动物模型中环核苷酸门控通道亚基β1（Cngb1）的表达是否与精神分裂症的病理生理学存在任何关联，以及人类基因的遗传多态性是否与韩国人群中精神分裂症的进展相关。
我们研究了在母体免疫激活诱导的精神分裂症小鼠模型中，Cngb1表达是否与精神疾病有关。对275例精神分裂症患者和410例对照进行了一项病例对照研究，检测了[具体基因名称]5'近端区域的单核苷酸多态性（SNP）。
在小鼠模型的前额叶皮质中，Cngb1表达降低。此外，[具体基因名称]的一个SNP（rs3756314）的基因型频率与精神分裂症风险相关。
我们的结果表明，[具体基因名称]可能与精神分裂症易感性和母体免疫激活有关。因此，推测[具体基因名称]可能参与精神分裂症的病理生理学过程。
