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极低出生体重儿坏死性小肠结肠炎：一项系统综述

Necrotizing enterocolitis in very low birth weight infants: a systemic review.

作者信息

Patel Bhoomika K, Shah Jigna S

机构信息

Department of Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Gujarat, Mehsana 384001, India.

出版信息

ISRN Gastroenterol. 2012;2012:562594. doi: 10.5402/2012/562594. Epub 2012 Sep 10.

DOI:10.5402/2012/562594
PMID:22997587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3444861/
Abstract

Necrotizing enterocolitis (NEC) is the most common serious gastrointestinal disorder affecting very preterm or very low birth weight infants. The risk is inversely proportional to gestational age and weight at birth. Fetal growth restriction and compromise may be additional specific risk factors. Despite extensive research and animal studies etiopathogenesis, preventive strategies and management options remain controversial. The present paper reviews the literature for recent advances and newer insights for changing epidemiological trends, pathogenesis, role of inflammatory cytokines, and various preventive and management strategies.

摘要

坏死性小肠结肠炎（NEC）是影响极早产儿或极低出生体重儿的最常见的严重胃肠道疾病。风险与胎龄和出生体重成反比。胎儿生长受限和窘迫可能是另外的特定风险因素。尽管对病因发病机制进行了广泛研究和动物实验，但预防策略和管理方案仍存在争议。本文综述了文献中关于不断变化的流行病学趋势、发病机制、炎性细胞因子的作用以及各种预防和管理策略的最新进展和新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e038/3444861/97b1da6184c4/ISRN.GASTROENTEROLOGY2012-562594.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e038/3444861/97b1da6184c4/ISRN.GASTROENTEROLOGY2012-562594.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e038/3444861/97b1da6184c4/ISRN.GASTROENTEROLOGY2012-562594.001.jpg

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本文引用的文献

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Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial.口服益生菌预防极低出生体重早产儿坏死性小肠结肠炎：一项多中心、随机、对照试验。
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凝血酶预处理的间充质基质细胞衍生的细胞外囊泡可减轻实验性坏死性小肠结肠炎。
Stem Cell Res Ther. 2025 Feb 28;16(1):101. doi: 10.1186/s13287-025-04243-3.
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Therapeutic Potential of Gut Microbiota and Its Metabolite Short-Chain Fatty Acids in Neonatal Necrotizing Enterocolitis.肠道微生物群及其代谢产物短链脂肪酸在新生儿坏死性小肠结肠炎中的治疗潜力
Life (Basel). 2023 Feb 16;13(2):561. doi: 10.3390/life13020561.
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