Gribovskaia O V, Martinovich V P, Golubovich V P, Ianchenko V V, Vykhristenko L R, Novikov D K
Bioorg Khim. 2012 May-Jun;38(3):291-9. doi: 10.1134/s1068162012030041.
High-affinity receptor FcepsilonR1 is a key substance which participates in IgE-dependent allergic reactions of immediate type. A minimal sequence Arg136-Asn137-Trp138-Asp139, which takes part in binding with C3 and C4 fragments of IgE was determined by methods of computer analysis. As possible analogs of FcepsilonR1 receptor, capable of binding to Fc-fragment IgE, a number of peptide compounds containing this sequence were proposed. Biological researches have shown that these peptides possess immunobiological effect and bind to IgE. Studied the ability of peptides to bind with IgE class serum antibodies specific to allergen Dermatophagoides pteronyssinus in patients with allergic bronchial asthma.
高亲和力受体FcepsilonR1是参与即刻型IgE依赖性过敏反应的关键物质。通过计算机分析方法确定了一个参与与IgE的C3和C4片段结合的最小序列Arg136 - Asn137 - Trp138 - Asp139。作为能够与Fc片段IgE结合的FcepsilonR1受体的可能类似物，提出了许多含有该序列的肽化合物。生物学研究表明，这些肽具有免疫生物学效应并能与IgE结合。研究了这些肽与过敏性支气管哮喘患者中针对变应原屋尘螨的IgE类血清抗体结合的能力。
