Mel'nichenko M A, Mal'tseva N V, Onishchenko A L, Lykova O F, Konysheva T V, Zabelin V I
Med Tr Prom Ekol. 2012(6):7-13.
The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of a forward piece of eyes. Chronic inflammatory diseases (blepharitis, conjunctivitis and blepharoconjunctivitis) are found at 28,9% of them, and dystrophic diseases (pinguecula/pterygium)--at 25,8%. Among metallurgists (1801 persons) ophthalmopathy was found in 2, 2 times more often than at persons in control group (110 observed engineers and managers). Two polymorphisms of cytochrome P450 1A1 (CYP1A1) and P-450 2E1 (CYP2E1) genes were defined in 91 workers, by the method of allele-specific polymerase chain reaction. It is revealed that CYP1A1 Ile462Val polymorphism associates with pinguecula/pterygium, raising risk of their development almost in 3 times, unlike CYP 2E1 -1293G/C polymorphism. Development of chronic inflammatory diseases is not connected with tested polymorphisms.
对两家冶金企业工人的眼科调查显示，在1911名接受观察的工人中，有1045人（55%）患有眼前部慢性疾病。其中，28.9%的人患有慢性炎症性疾病（睑缘炎、结膜炎和睑结膜炎），25.8%的人患有营养不良性疾病（睑裂斑/翼状胬肉）。在冶金工人（1801人）中，眼病的发病率是对照组（110名接受观察的工程师和管理人员）的2.2倍。通过等位基因特异性聚合酶链反应方法，在91名工人中确定了细胞色素P450 1A1（CYP1A1）和P - 450 2E1（CYP2E1）基因的两种多态性。结果显示，与CYP 2E1 - 1293G/C多态性不同，CYP1A1 Ile462Val多态性与睑裂斑/翼状胬肉相关，使其发病风险增加近3倍。慢性炎症性疾病的发生与所检测的多态性无关。
