[眼前段慢性炎症和营养不良性疾病及其与冶金行业工人基因多态性的关联]
[Chronic inflammatory and dystrophic diseases of the eye anterior segment and their association with genetic polymorphisms in workers of metallurgic industry].
作者信息
Mel'nichenko M A, Mal'tseva N V, Onishchenko A L, Lykova O F, Konysheva T V, Zabelin V I
出版信息
Med Tr Prom Ekol. 2012(6):7-13.
The ophthalmologic investigation of workers of the two metallurgical enterprises has shown that 1045 persons (55%) from 1911 observed workers suffer chronic diseases of a forward piece of eyes. Chronic inflammatory diseases (blepharitis, conjunctivitis and blepharoconjunctivitis) are found at 28,9% of them, and dystrophic diseases (pinguecula/pterygium)--at 25,8%. Among metallurgists (1801 persons) ophthalmopathy was found in 2, 2 times more often than at persons in control group (110 observed engineers and managers). Two polymorphisms of cytochrome P450 1A1 (CYP1A1) and P-450 2E1 (CYP2E1) genes were defined in 91 workers, by the method of allele-specific polymerase chain reaction. It is revealed that CYP1A1 Ile462Val polymorphism associates with pinguecula/pterygium, raising risk of their development almost in 3 times, unlike CYP 2E1 -1293G/C polymorphism. Development of chronic inflammatory diseases is not connected with tested polymorphisms.
对两家冶金企业工人的眼科调查显示，在1911名接受观察的工人中，有1045人（55%）患有眼前部慢性疾病。其中，28.9%的人患有慢性炎症性疾病（睑缘炎、结膜炎和睑结膜炎），25.8%的人患有营养不良性疾病（睑裂斑/翼状胬肉）。在冶金工人（1801人）中，眼病的发病率是对照组（110名接受观察的工程师和管理人员）的2.2倍。通过等位基因特异性聚合酶链反应方法，在91名工人中确定了细胞色素P450 1A1（CYP1A1）和P - 450 2E1（CYP2E1）基因的两种多态性。结果显示，与CYP 2E1 - 1293G/C多态性不同，CYP1A1 Ile462Val多态性与睑裂斑/翼状胬肉相关，使其发病风险增加近3倍。慢性炎症性疾病的发生与所检测的多态性无关。
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