Zhao Qing, Wan Yigang, Wang Chaojun, Wei Qingxue, Chen Haoli, Meng Xianjie, Yao Jian
Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1700-4.
The inflammatory reaction of renal tissues and its relevant tissue damages (such as glomerulosclerosis and renal interstitial fibrosis) are important factors for the development of chronic kidney diseases (CKD) to end-state renal diseases. Of them, p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in regulating expression and bioactivity of multiple nuclear transcription factors, impacting synthesis of downstream inflammatory mediators and activating inflammatory cells. Some monomer traditional Chinese medicines and their extracts (such as emodin and berberine) and some traditional Chinese medicine compound prescriptions (such as Yishen Huoxue decoction) can affect inflammatory reaction of renal tissues by regulating p38MAPK signaling pathway, thas improving reduce glomerulus and renal interstitial inflammatory injury.
肾组织的炎症反应及其相关的组织损伤（如肾小球硬化和肾间质纤维化）是慢性肾脏病（CKD）发展至终末期肾病的重要因素。其中，p38丝裂原活化蛋白激酶（MAPK）信号通路在调节多种核转录因子的表达和生物活性、影响下游炎症介质的合成以及激活炎症细胞方面发挥着重要作用。一些单味中药及其提取物（如大黄素和黄连素）以及一些中药复方制剂（如益肾活血汤）可通过调节p38MAPK信号通路影响肾组织的炎症反应，从而减轻肾小球和肾间质的炎性损伤。
