Chen Hao-Li, Wan Yi-Gang, Zhao Qing, Huang Yan-Ru, Shi Xi-Miao, Meng Xian-Jie, Yao Jian
Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China.
Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(14):2268-72.
It is reported, in the process of diabetic nephropathy (DN), inflammatory-related p38 mitogen-activated protein kinase (MAPK) signaling pathway has a close relationship with renal injury. On the one hand,many factors in the upstream including hyperglycemia, abnormal hemodynamics, oxidative stress, and pro-inflammatory cytokines could activate p38MAPK signaling pathway. On the other hand,the activated p38MAPK signaling pathway could lead to renal damage via activating inflammatory cells, inducing the expression of inflammatory mediators, and intervening cytokines production. CHM could intervene p38MAPK signaling pathway through multi-ways, including inhibiting inflammatory cytokines expression, regulating phosphorylated p38MAPK (p-p38MAPK) expression, and reducing fibrogenic factors expression.
据报道，在糖尿病肾病（DN）进程中，炎症相关的p38丝裂原活化蛋白激酶（MAPK）信号通路与肾损伤密切相关。一方面，包括高血糖、异常血流动力学、氧化应激和促炎细胞因子在内的多种上游因素可激活p38MAPK信号通路。另一方面，激活的p38MAPK信号通路可通过激活炎症细胞、诱导炎症介质表达以及干预细胞因子产生导致肾损伤。中药复方（CHM）可通过多种途径干预p38MAPK信号通路，包括抑制炎症细胞因子表达、调节磷酸化p38MAPK（p-p38MAPK）表达以及降低纤维化因子表达。
