Shu Li-Juan, Wei Xin-Chuan
Department of Anesthesia, West China Hospital, Sichuan University, Sichuan 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Jul;43(4):543-6.
To investigate whether Penehyclidine hydrochloride has effect on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass.
40 rheumatic heart disease patients undergoing CPB were randomly divided into Penehyclidine hydrochloride (P) group and control (C) group (20 patients in each group). In group P, intravenous drip of 0.01 mg/kg of Penehyclidine hydrochloride injection was given before anesthesia, and 0. 015 mg/kg of Penehyclidine hydrochloride was added into initial volume of CPB. While in control group, 0.9% NaCl solution was given instead of injection as a placebo. Blood samples were taken before anesthesia (T0), 30 min after CPB (T1), 10 min after aortic off-clamping (T2) and 2 hours when CPB was over (T3). Interleukin-6 (IL-6), tumornecross alpha (TNF-alpha) levels were detected by ELISA. The morbility of pneumonia and SIRS caused by CPB was also evaluated.
At T2 and T3, the IL-6 level was higher than T0 and T1 both in group C and group P (P < 0.05). At T2 and T3, the IL-6 level in group C was higher than that of group P (P < 0.05). The TNF-alpha level at T3 was lower than at T1 and T2 in group P (P < 0.05). There was no significant difference between group P and group C at each time point (P > 0.05). The morbility of pneumonia and SIRS was higher in group C (P < 0.05).
Penehyclidine hydrochloride can decrease the levels of proinflamnlatory cytokines in plasma and therefore attenuate the morbility of pneumonia and SIRS caused by CPB.
探讨盐酸戊乙奎醚对体外循环心脏手术患者炎症反应过程及白细胞的影响。
将40例行体外循环的风湿性心脏病患者随机分为盐酸戊乙奎醚（P）组和对照组（C），每组20例。P组于麻醉前静脉滴注0.01mg/kg盐酸戊乙奎醚注射液，体外循环预充液中加入0.015mg/kg盐酸戊乙奎醚；C组用0.9%氯化钠溶液作为安慰剂替代注射液。分别于麻醉前（T0）、体外循环30min后（T1）、主动脉开放阻断10min后（T2）及体外循环结束2h时（T3）采集血样，采用酶联免疫吸附测定法检测白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平，并评估体外循环导致的肺炎及全身炎症反应综合征（SIRS）的发生率。
T2及T3时，C组和P组IL-6水平均高于T0及T1（P<0.05）；T2及T3时，C组IL-6水平高于P组（P<0.05）。P组T3时TNF-α水平低于T1及T2（P<0.05），各时间点P组与C组比较差异无统计学意义（P>0.05）。C组肺炎及SIRS发生率较高（P<0.05）。
盐酸戊乙奎醚可降低血浆促炎细胞因子水平，减轻体外循环导致的肺炎及SIRS的发生率。
