Lei Yi, Chen Bo-Jiang, Zeng Li, Li Wei-Min
General Ward, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Jul;43(4):584-7.
To analyze the value of low-dose computed tomography (LDCT) in early screening of lung cancer in high-risk group.
LDCT was performed in 1551 adults over 40-years old (male 1054, female 497) for the screening of lung cancer in Examination Center of West China Hospital, Sichuan University, and the subjects were divided into high-risk group and non-high-risk group according to risk factors of lung caner. The detection rates of lung lesion and lung cancer in these two groups were carefully analyzed.
In the people over 40-years old,the detection rate of pulmonary lesions by LDCT was 54.41% (844/1551), the detection rate of nodules was 29.4% (456/1551). Detection rate of lung cancer was 0.51% (8/1551), while it was 1.21% (7/577) in high-risk group, and 2.01% (6/298) in heavy smoker group. The difference of lung cancer detection rate was significant (P < 0.05). When stratified with the number of risk factors, the detection rate of lung cancer by LDCT was 0.10% (1/974) in the subjects without any high-risk factors, 0.98% (5/506) in the subjects with one high-risk factor and 2.86% (2/70) in the subjects with more high-risk factors, and the differences were stastatically significant (P < 0.05).
LDCT can detect asymptomatic lung cancer sensitively with low radiation dose, which could be helpful for the screening of lung cancer.
分析低剂量计算机断层扫描（LDCT）在肺癌高危人群早期筛查中的价值。
对四川大学华西医院体检中心1551名40岁以上成年人（男性1054名，女性497名）行LDCT肺癌筛查，根据肺癌危险因素将研究对象分为高危组和非高危组，仔细分析两组肺病变及肺癌的检出率。
40岁以上人群中，LDCT肺病变检出率为54.41%（844/1551），结节检出率为29.4%（456/1551）。肺癌检出率为0.51%（8/1551），高危组为1.21%（7/577），重度吸烟组为2.01%（6/298）。肺癌检出率差异有统计学意义（P<0.05）。按危险因素个数分层时，无任何高危因素者LDCT肺癌检出率为0.10%（1/974），有1个高危因素者为0.98%（5/506），有多个高危因素者为2.86%（2/70），差异有统计学意义（P<0.05）。
LDCT能以低辐射剂量敏感地检测出无症状肺癌，有助于肺癌筛查。
