Medical Oncology Department, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice Cedex 2, France.
Lung Cancer. 2012 Dec;78(3):282-4. doi: 10.1016/j.lungcan.2012.08.015. Epub 2012 Sep 19.
Few descriptions of miliary brain metastases have been reported. We report the case of an adenocarcinoma of the lung associated with metachronous miliary brain and lung metastases with an echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation. The patient was treated with crizotinib and showed a twelve-month progression-free survival. Clinicians should be attentive of the evolution of brain metastases with patients presenting EML4-ALK translocation.
鲜有关于脑多发性转移瘤的描述。我们报告了一例肺腺癌伴脑和肺多发性转移瘤的病例，该转移瘤存在棘皮动物微管相关蛋白样 4-间变性淋巴瘤激酶（EML4-ALK）基因易位。该患者接受了克唑替尼治疗，无进展生存期为 12 个月。对于存在 EML4-ALK 易位的患者，临床医生应注意其脑转移瘤的演变。
