Russo Alessandro, Franchina Tindara, Ricciardi Giuseppina Rosaria Rita, Fanizza Caterina, Scimone Antonino, Chiofalo Giuseppe, Giordano Antonio, Adamo Vincenzo
Medical Oncology Unit A.O. Papardo & Department of Human Pathology University of Messina, Italy.
Fondazione Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
Oncotarget. 2017 Jan 31;8(5):8717-8725. doi: 10.18632/oncotarget.14427.
Epidermal Growth Factor Receptor (EGFR) mutated Non Small Cell Lung Cancers (NSCLCs) are a molecularly subgroup of patients with peculiar clinic-pathological characteristics. Previous studies have suggested a possible interaction between oncogene status and metastatic behavior in non squamous NSCLCs with conflicting results. The aim of this study was to compare the different metastatic patterns, at baseline and during the course of the disease, in a cohort of 137 Caucasian patients with non-squamous NSCLC according to the EGFR mutational status and survival differences according to the different metastatic behavior. We observed unique metastatic distributions between EGFR-mutated and EGFR wild type non-squamous NSCLCs. These data support the hypothesis that tumor bio-molecular characteristics and genotype may influence the metastatic process in NSCLC and might help the development of enrichment strategies for tumor genotyping in these tumors, especially in the presence of limited tissue availability.
表皮生长因子受体（EGFR）突变的非小细胞肺癌（NSCLC）是具有独特临床病理特征患者的一个分子亚组。先前的研究表明，在非鳞状NSCLC中，癌基因状态与转移行为之间可能存在相互作用，但结果相互矛盾。本研究的目的是比较137例白种人非鳞状NSCLC患者队列中，根据EGFR突变状态在基线和疾病过程中的不同转移模式，以及根据不同转移行为的生存差异。我们观察到EGFR突变型和EGFR野生型非鳞状NSCLC之间独特的转移分布。这些数据支持以下假设：肿瘤生物分子特征和基因型可能影响NSCLC的转移过程，并可能有助于制定这些肿瘤的肿瘤基因分型富集策略，尤其是在组织样本有限的情况下。
