Yoshida K, Kiso Y, Watanabe T K, Kaise K, Kaise N, Itagaki Y, Yamamoto M, Sakurada T, Yoshinaga K
Department of Clinical Biology and Hormonal Regulation, Tohoku University School of Medicine, Sendai, Japan.
Metabolism. 1990 Feb;39(2):182-6. doi: 10.1016/0026-0495(90)90073-l.
Red blood cell (RBC) zinc (Zn) concentration was measured by atomic absorption spectrophotometry in 28 healthy volunteers, in 46 patients with hyperthyroidism, and in 6 patients with hypothyroidism. The mean (+/- SD) RBC Zn concentration in euthyroid controls was 11.4 +/- 1.5 mg/L RBC, and the normal range defined as the mean +/- 2 SD was 8.5 to 14.3 mg/L RBC. The mean RBC Zn in patients with hyperthyroidism was decreased to 6.4 +/- 1.6 mg/L RBC, and 43 (93%) had low values. The mean RBC Zn in patients with hypothyroidism was not different from that in the controls. There was a significant negative correlation between the concentrations of RBC Zn and those of both plasma thyroxine (T4; r = -0.73) and plasma 3,5,3'-triiodothyronine (T3; r = -0.70). After the treatment of 17 hyperthyroid patients with antithyroid drugs, both mean plasma T4 and T3 levels became normal within 4 weeks, but the normalization of RBC Zn lagged about 2 months behind them. The RBC Zn levels significantly correlated with both the plasma T4 and T3 levels obtained 0, 4, 8, and 12 weeks prior to the RBC sampling, and the highest correlation was observed between the RBC Zn levels and plasma T4 and T3 levels measured 8 weeks previously. These data suggest that RBC Zn concentration in hyperthyroid patients reflects a patient's mean thyroid hormone level over the preceding several months as glycosylated hemoglobin level does in diabetic patients.
采用原子吸收分光光度法对28名健康志愿者、46例甲状腺功能亢进患者和6例甲状腺功能减退患者的红细胞（RBC）锌（Zn）浓度进行了测定。甲状腺功能正常对照组的红细胞锌浓度均值（±标准差）为11.4±1.5mg/L RBC，定义为均值±2标准差的正常范围为8.5至14.3mg/L RBC。甲状腺功能亢进患者的红细胞锌均值降至6.4±1.6mg/L RBC，43例（93%）患者的红细胞锌值较低。甲状腺功能减退患者的红细胞锌均值与对照组无差异。红细胞锌浓度与血浆甲状腺素（T4；r = -0.73）和血浆三碘甲状腺原氨酸（T3；r = -0.70）浓度之间存在显著负相关。17例甲状腺功能亢进患者接受抗甲状腺药物治疗后，4周内血浆T4和T3水平均恢复正常，但红细胞锌的恢复正常比它们滞后约2个月。红细胞锌水平与红细胞采样前0、4、8和12周测得的血浆T4和T3水平均显著相关，且在红细胞锌水平与8周前测得的血浆T4和T3水平之间观察到最高相关性。这些数据表明，甲状腺功能亢进患者的红细胞锌浓度反映了患者前几个月的平均甲状腺激素水平，就像糖尿病患者的糖化血红蛋白水平一样。
