Kakizaki Manabu, Nobori Kiyoshi, Watanabe Hiroyuki, Iino Kenji, Ishida Masaru, Ito Hiroshi
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, 1-1-1, Hondo, Akita, 010-8543, Japan.
Heart Vessels. 2013 Sep;28(5):566-9. doi: 10.1007/s00380-012-0284-z. Epub 2012 Sep 23.
The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD). Recent studies have identified a novel T-cell subset labeled with CD3(+)/CD31(+), which is necessary for EPC colony formation and constitutes the central cluster. However, the clinical relevance of the CD3(+)/CD31(+) T cells in CAD remains unclear. We sought to clarify whether circulating CD3(+)/CD31(+) T cells are increased in patients with acute coronary syndrome (ACS). Circulating CD3(+)/CD31(+) T cells were determined in 16 ACS patients undergoing emergency percutaneous coronary intervention (PCI) and in 16 control subjects with angiographically normal coronary arteries. Although no differences between the groups were found in baseline patient characteristics, the ratio of circulating CD3(+)/CD31(+) T cells before PCI was higher in ACS patients as compared with that in control subjects (51.8 % ± 7.8 % vs 31.8 % ± 9.6 %, respectively; P < 0.001). The increased ratio of CD3(+)/CD31(+) T cells in ACS patients was not altered 24 h after PCI, but became comparable with that in control subjects within 6 months after PCI. These results suggest that mobilization of CD3(+)/CD31(+) T cells occurs in ACS, but is no longer detectable at 6 months after PCI.
循环内皮祖细胞（EPCs）的数量被认为是冠状动脉疾病（CAD）的替代标志物。最近的研究发现了一种标记为CD3(+)/CD31(+)的新型T细胞亚群，它是EPC集落形成所必需的，并构成中心簇。然而，CD3(+)/CD31(+) T细胞在CAD中的临床相关性仍不清楚。我们试图阐明急性冠状动脉综合征（ACS）患者循环中的CD3(+)/CD31(+) T细胞是否增加。对16例接受急诊经皮冠状动脉介入治疗（PCI）的ACS患者和16例冠状动脉造影正常的对照受试者测定循环CD3(+)/CD31(+) T细胞。虽然两组患者的基线特征没有差异，但与对照受试者相比，ACS患者PCI术前循环CD3(+)/CD31(+) T细胞的比例更高（分别为51.8%±7.8%和31.8%±9.6%；P<0.001）。ACS患者CD3(+)/CD31(+) T细胞比例的增加在PCI术后24小时没有改变，但在PCI术后6个月内与对照受试者相当。这些结果表明，CD3(+)/CD31(+) T细胞在ACS中发生动员，但在PCI术后6个月不再可检测到。
