Medical Intensive Care Unit, Saint-Louis University Hospital, APHP, Paris, France.
Intensive Care Med. 2012 Nov;38(11):1751-60. doi: 10.1007/s00134-012-2692-z. Epub 2012 Sep 22.
To describe the method and significance of Doppler-based resistive index (RI) and to provide an updated description of its interest with a special focus on the critically ill.
Review of selected studies on RI found in the PubMed, Ovid and Cochrane databases. Additional references were retrieved from the selected studies.
An increasing body of evidence suggests that renal Doppler may help to assess perfusion of native or transplanted kidneys. In addition, recent studies suggest that it may be useful in critically ill patients. The RI is a parameter derived from Doppler examination that is calculated as follows: [Formula: see text]. Renal Doppler has proven to be valuable for assessing large arterial or venous abnormalities and has been suggested to assess renal perfusion and to predict acute kidney injury (AKI) in critically ill patients. However, numerous factors have been shown to influence renal Doppler and may constitute potential confounding factors. Moreover, experience with critically ill patients is scant and our understanding of factors influencing RI in this setting is limited.
Doppler-based RI seems to be a promising tool in the critically ill to assess the risk of AKI, help in differentiating persistent from transient AKI, or assess changes in renal perfusion as consequences of therapeutic intervention. However, we still lack large, adequately powered studies in non-selected populations of patients before implementing this technique in clinical practice. In addition, the impact of several factors that may influence this parameter remains to be evaluated.
描述基于多普勒的阻力指数(RI)的方法和意义,并特别关注危重症患者,提供其最新的研究兴趣描述。
在 PubMed、Ovid 和 Cochrane 数据库中检索关于 RI 的选定研究进行综述。从选定的研究中检索到其他参考文献。
越来越多的证据表明,肾脏多普勒超声可能有助于评估天然或移植肾脏的灌注。此外,最近的研究表明,它可能对危重症患者有用。RI 是从多普勒检查中得出的一个参数,计算方法如下:[公式:见正文]。肾脏多普勒超声已被证明对评估大的动脉或静脉异常非常有价值,并已被建议用于评估危重症患者的肾灌注,并预测急性肾损伤(AKI)。然而,许多因素已被证明会影响肾脏多普勒超声,并可能构成潜在的混杂因素。此外,危重症患者的经验有限,我们对该环境中影响 RI 的因素的理解也有限。
基于多普勒的 RI 似乎是危重症患者评估 AKI 风险的一种很有前途的工具,有助于区分持续性和短暂性 AKI,或评估治疗干预后肾灌注的变化。然而,在将该技术应用于临床实践之前,我们仍缺乏在非选择性患者人群中进行的大型、充分的研究。此外,仍需要评估可能影响该参数的几个因素的影响。