Kafka M S, Lake C R, Gullner H G, Tallman J F, Bartter F C, Fujita T
Clin Exp Hypertens (1978). 1979;1(5):613-27. doi: 10.3109/10641967909068628.
As plasma norepinephrine (NE) levels may be similar in hypertensive and normotensive subjects, the sensitivity of adrenergic receptors was investigated in patients with essential hypertension and normotensive subjects of similar age and sex. Alpha-adrenergic receptor sensitivity was measured in platelets by the specific binding of [3H]dihydroergocryptine and the NE inhibition of prostaglandin E1 (PGE1)-stimulated cyclic AMP (cAMP) production. The number of alpha-adrenergic receptors in platelets from hypertensive women was 1.5 times that in the platelets from normotensive ones, with no differences between hypertensive and normotensive women or between men and women in the affinity of the alpha-adrenergic receptor for [3H]dihydroergocryptine. PGE1-stimulated cAMP production was half as great in hypertensive as in normotensive men, while NE inhibition of PGE1-stimulated cAMP production was similar in hypertensive and normotensive men and women. [3H]Dihydroergoeryptine binding in female hypertensives, and PGE1-stimulated cAMP in male hypertensives did not differ from that in sex-matched controls. The sensitivity of the beta-adrenergic receptor, measured by [3H]dihydroalprenolol binding and cAMP production was similar in hypertensive and normotensive subjects.
由于高血压患者和血压正常者的血浆去甲肾上腺素（NE）水平可能相似，因此研究了原发性高血压患者以及年龄和性别相似的血压正常者的肾上腺素能受体敏感性。通过[3H]二氢麦角隐亭的特异性结合以及NE对前列腺素E1（PGE1）刺激的环磷酸腺苷（cAMP）产生的抑制作用，来测量血小板中的α-肾上腺素能受体敏感性。高血压女性血小板中的α-肾上腺素能受体数量是血压正常女性血小板中受体数量的1.5倍，高血压女性和血压正常女性之间，以及男性和女性之间，α-肾上腺素能受体对[3H]二氢麦角隐亭的亲和力没有差异。在高血压男性中，PGE1刺激的cAMP产生量只有血压正常男性的一半，而在高血压男性和女性以及血压正常男性和女性中，NE对PGE1刺激的cAMP产生的抑制作用相似。女性高血压患者中[3H]二氢麦角隐亭的结合以及男性高血压患者中PGE1刺激的cAMP与性别匹配的对照组没有差异。通过[3H]二氢阿普洛尔结合和cAMP产生来测量的β-肾上腺素能受体敏感性在高血压患者和血压正常者中相似。
