Kanof P D, Johns C A, Davidson M, Siever L J, Coccaro E F, Davis K L
Psychiatry Service, Bronx VA Medical Center, NY 10468.
Psychiatry Res. 1988 Jan;23(1):11-22. doi: 10.1016/0165-1781(88)90030-3.
The inhibitory effects of norepinephrine (NE) on the cyclic adenosine-3',5'-monophosphate (cAMP) response to prostaglandin E1 (PGE1), a measure of alpha 2-adrenergic receptor function, have been compared in platelets from drug-free schizophrenic patients, depressive patients, and normal controls. The absolute value of the inhibition by NE of the cAMP response to PGE1 was smaller in platelets from schizophrenic and depressive patients than in controls. However, this result was secondary to the smaller baseline platelet cAMP response to PGE1 in patients with these disorders. Effects of NE on cAMP production did not discriminate between actively ill and remitted patients with either schizophrenia or depression. Platelet alpha 2-receptor sensitivity, as measured by the effects of NE on cAMP production, does not appear to be altered in these psychiatric disorders.
已比较了去甲肾上腺素（NE）对前列腺素E1（PGE1）引起的环磷酸腺苷（cAMP）反应的抑制作用（一种α2 - 肾上腺素能受体功能的指标），该实验在未服用药物的精神分裂症患者、抑郁症患者及正常对照者的血小板中进行。精神分裂症患者和抑郁症患者血小板中，NE对PGE1引起的cAMP反应的抑制绝对值低于对照组。然而，这一结果是由于这些疾病患者血小板对PGE1的基线cAMP反应较小所致。NE对cAMP产生的影响在精神分裂症或抑郁症的活动期患者和缓解期患者之间没有差异。通过NE对cAMP产生的影响来衡量，血小板α2 - 受体敏感性在这些精神疾病中似乎未发生改变。
