French Agency for Food, Environmental and Occupational Health and Safety (ANSES), Nancy Laboratory for Rabies and Wildlife, European Union Reference Laboratory for rabies, European Union Reference Laboratory for rabies serology, OIE Reference Laboratory for rabies, WHO Collaborating centre for research and management in zoonoses control, Technopôle agricole et vétérinaire, BP 40009, 54 220 Malzéville Cedex, France.
Arch Virol. 2013 Jan;158(1):237-40. doi: 10.1007/s00705-012-1466-9. Epub 2012 Sep 23.
Rabies, a worldwide zoonosis, remains a public-health concern despite oral wildlife vaccination in Europe. After a ten-year break, Macedonia reported eight rabies cases in 2011-2012. Two countries (Serbia and Bulgaria) bordering Macedonia are reporting cases in domestic and wild animals. This report describes the genetic characterisation of eight isolates from Macedonia compared with representative samples from neighbouring countries. All of the isolates tested belong to the Eastern European group, with a high degree of nucleotide sequence identity in the nucleoprotein gene. The close genetic relationship between isolates from the three bordering countries suggests that wildlife is responsible for rabies movements in the region.
狂犬病是一种全球性的动物传染病，尽管在欧洲已经开展了针对野生动物的口服疫苗接种，但它仍然是公共卫生关注的问题。在中断十年后，马其顿于 2011-2012 年报告了 8 例狂犬病病例。与马其顿接壤的两个国家（塞尔维亚和保加利亚）报告了国内和野生动物中的病例。本报告描述了与来自邻国的代表性样本相比，来自马其顿的 8 个分离株的遗传特征。所有测试的分离株均属于东欧群，在核蛋白基因中有高度的核苷酸序列同一性。来自这三个接壤国家的分离株之间的密切遗传关系表明，野生动物是该地区狂犬病传播的原因。
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