Universidade Estadual Paulista, UNESP, Rua Clóvis Pestana, 793, Araçatuba, SP 16050-680, Brazil.
Arch Virol. 2012 Jan;157(1):93-105. doi: 10.1007/s00705-011-1146-1. Epub 2011 Oct 28.
This epidemiological study was conducted using antigenic and genetic characterisation of rabies virus isolates obtained from different animal species in the southeast of Brazil from 1993 to 2007. An alteration in the epidemiological profile was observed. One hundred two samples were tested using a panel of eight monoclonal antibodies, and 94 were genetically characterised by sequencing the nucleoprotein gene. From 1993 to 1997, antigenic variant 2 (AgV-2), related to a rabies virus maintained in dog populations, was responsible for rabies cases in dogs, cats, cattle and horses. Antigenic variant 3 (AgV-3), associated with Desmodus rotundus, was detected in a few cattle samples from rural areas. From 1998 to 2007, rabies virus was detected in bats and urban pets, and four distinct variants were identified. A nucleotide similarity analysis resulted in two primary groups comprising the dog and bat antigenic variants and showing the distinct endemic cycles maintained in the different animal species in this region.
本项流行病学研究采用抗原和遗传特征分析方法，对 1993 年至 2007 年期间巴西东南部不同动物物种的狂犬病病毒分离株进行了研究。研究观察到流行病学特征的改变。使用一组 8 种单克隆抗体对 102 个样本进行了检测，并用核蛋白基因测序对 94 个样本进行了基因特征分析。1993 年至 1997 年，与狗群中维持的狂犬病病毒相关的抗原变异 2（AgV-2）导致了狗、猫、牛和马的狂犬病病例。与吸血蝙蝠相关的抗原变异 3（AgV-3）在一些农村地区的牛样本中被检测到。1998 年至 2007 年，在蝙蝠和城市宠物中检测到了狂犬病病毒，并鉴定出了 4 种不同的变异株。核苷酸相似性分析结果表明，存在两个主要组，包括狗和蝙蝠的抗原变异株，并显示了该地区不同动物物种中维持的不同地方性流行周期。
