离子标记的 box-Cu(OAc)2 配合物的非共价固定化及其在不对称 Henry 反应中的应用。
Noncovalent immobilization of ionic-tagged box-Cu(OAc)2 complex and its application in asymmetric Henry reaction.
机构信息
R&D Centre for Pharmaceuticals, School of Chemical Engineering and Environment, Beijing Institute of Technology, People's Republic of China.
出版信息
Chirality. 2012 Dec;24(12):1092-5. doi: 10.1002/chir.22104. Epub 2012 Sep 24.
Immobilized Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding by SBA-15 was applied to asymmetric Henry reaction, and good enantioselectivities were obtained (up to 83% ee) between 2-methoxybenzaldehyde and CH(3)NO(2) in isopropyl alcohol (iPrOH). The catalyst could be reused seven times without any obvious loss in enantioselectivity. For the first time, this facile and clean immobilization method is applied to the use of bis(oxazolines) complexes.
通过 SBA-15 氢键固定化的 Cu(OAc)(2)-双恶唑啉被应用于不对称 Henry 反应，在异丙醇（iPrOH）中，2-甲氧基苯甲醛和 CH(3)NO(2)之间获得了良好的对映选择性（高达 83%ee）。催化剂在没有明显损失对映选择性的情况下可以重复使用七次。这是首次将这种简便、清洁的固定化方法应用于双恶唑啉配合物的使用。
Zotero 插件