Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
J Clin Lab Anal. 2012 Sep;26(5):398-402. doi: 10.1002/jcla.21541.
Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity. The aim of the present study was to explore the relationship of leptin and adiponectin levels with cardiovascular risk factors and anthropometric parameters in patients with PHTP with and without metabolic syndrome (MS).
A total of 62 patients with PHPT were enrolled. Weight, blood pressure, basal glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, insulin, HOMA-R, intact parathormone, vitamin D, calcium, leptin, and adiponectin levels were measured in fasting condition.
Prevalence of MS with ATP III definition was 32.3% (20 patients; 15 females (75%) and 5 males (25%)) and 67.7% patients without MS (n = 42 patients; 35 females (83.3%) and 7 males (16.7%)). In the analysis with leptin as dependent variable, the weight and HOMA-R levels remained in the model (F = 9.2; P < 0.05), with an increase of 1.31 (CI 95%: 0.24-2.31) ng/ml with each one unit of HOMA-R and an increase of 0.4 (CI 95%: 0.01-0.84) ng/ml with each 1 kg of weight. In a second model with adiponectin as dependent variable, the HOMA-R and HDL-cholesterol levels remained in the model (F = 7.37; P < 0.05), with a decrease of -0.62 (CI 95%: 0.01-1.1) ng/ml with each one point of HOMA-R and an increase of 0.18 (CI 95%: 0.04-0.38) ng/ml with each 1 mg/dl of HDL-cholesterol. In the multivariate, PTH I was not associated with other variables.
There was a high prevalence of MS-32.3% of patients with PHPT presented an MS. Serum levels of leptin and adiponectin are not related with PTH I, vitamin D, and calcium levels in patients with PHPT.
原发性甲状旁腺功能亢进症（PHPT）与较高的心血管发病率相关。本研究的目的是探讨 PHPT 患者中存在和不存在代谢综合征（MS）时，瘦素和脂联素水平与心血管危险因素和人体测量参数之间的关系。
共纳入 62 例 PHPT 患者。空腹测量体重、血压、基础血糖、胰岛素、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、胰岛素、HOMA-R、完整甲状旁腺素、维生素 D、钙、瘦素和脂联素水平。
根据 ATP III 定义，MS 的患病率为 32.3%（20 例患者；15 例女性（75%）和 5 例男性（25%）），67.7%的患者没有 MS（n=42 例；35 例女性（83.3%）和 7 例男性（16.7%））。在以瘦素为因变量的分析中，体重和 HOMA-R 水平仍保留在模型中（F=9.2；P<0.05），HOMA-R 每增加一个单位，瘦素增加 1.31ng/ml（95%CI：0.24-2.31），体重增加 1kg，瘦素增加 0.4ng/ml（95%CI：0.01-0.84）。在以脂联素为因变量的第二个模型中，HOMA-R 和高密度脂蛋白胆固醇水平仍保留在模型中（F=7.37；P<0.05），HOMA-R 每增加一个单位，脂联素减少-0.62ng/ml（95%CI：0.01-1.1），高密度脂蛋白胆固醇每增加 1mg/dl，脂联素增加 0.18ng/ml（95%CI：0.04-0.38）。在多变量分析中，PTH I 与其他变量没有相关性。
PHPT 患者中 MS 的患病率较高，32.3%的患者存在 MS。PHPT 患者的瘦素和脂联素水平与 PTH I、维生素 D 和钙水平无关。
