Al-Hraishawi Haidar, Dellatore Peter J, Cai Xinjiang, Wang Xiangbing
a Division of Endocrinology, Metabolism & Nutrition , Department of Medicine, Rutgers University-Robert Wood Johnson Medical School , New Brunswick , NJ , USA.
b Department of Medicine , Icahn School of Medicine at Mount Sinai (James J. Peters VA Bronx) , New York , NY , USA.
Endocr Res. 2017 Aug;42(3):241-245. doi: 10.1080/07435800.2017.1292528. Epub 2017 Mar 20.
The aim of this article is to compare clinical characteristics and lab values for metabolic syndrome between primary hyperparathyroidism (PHPT) patients with different levels of serum intact parathyroid hormone (iPTH) and to determine correlation between different clinical characteristics among PHPT patients Methods: We reviewed charts of 212 PHPT patients in this retrospective study. Patients were divided into two groups according to their initial serum iPTH levels. Student's t-tests were used to compare the two groups for differences in clinical characteristics and laboratory values. Pearson's correlation coefficients were used to assess associations.
Of the 212 PHPT patients, 100 were classified as m-iPTH group (serum iPTH < 140 pg/mL), whereas 112 patients were defined as h-iPTH group (serum iPTH ≥ 140 pg/mL). The h-iPTH patients were younger, had higher serum calcium and alkaline phosphatase levels, but exhibited lower 25(OH)-vitamin D and HDL levels, when compared with those of m-iPTH patients. Adenoma weights in the h-iPTH group tended to be higher than that in the m-iPTH group. Furthermore, association studies revealed that the iPTH level was positively correlated with adenoma weight and serum calcium and triglyceride (TG) levels but negatively correlated with HDL level.
Our study supports the hypothesis that iPTH level is associated with TG and HDL levels and should be a factor to consider in the management of PHPT patients.
本文旨在比较不同血清完整甲状旁腺激素（iPTH）水平的原发性甲状旁腺功能亢进症（PHPT）患者代谢综合征的临床特征和实验室值，并确定PHPT患者不同临床特征之间的相关性。方法：在这项回顾性研究中，我们查阅了212例PHPT患者的病历。根据患者初始血清iPTH水平将其分为两组。采用学生t检验比较两组患者的临床特征和实验室值差异。采用Pearson相关系数评估相关性。
在212例PHPT患者中，100例被分类为m-iPTH组（血清iPTH<140 pg/mL），而112例患者被定义为h-iPTH组（血清iPTH≥140 pg/mL）。与m-iPTH组患者相比，h-iPTH组患者更年轻，血清钙和碱性磷酸酶水平更高，但25（OH）-维生素D和高密度脂蛋白（HDL）水平更低。h-iPTH组腺瘤重量往往高于m-iPTH组。此外，关联研究显示，iPTH水平与腺瘤重量、血清钙和甘油三酯（TG）水平呈正相关，但与HDL水平呈负相关。
我们的研究支持以下假设，即iPTH水平与TG和HDL水平相关，应作为管理PHPT患者时考虑的一个因素。
