有机催化氮杂迈克尔-迈克尔级联反应：一种构建 2,3,4-三取代四氢喹啉的灵活方法。
Organocatalytic aza-Michael-Michael cascade reactions: a flexible approach to 2,3,4-trisubstituted tetrahydroquinolines.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
出版信息
Chemistry. 2012 Oct 8;18(41):12958-61. doi: 10.1002/chem.201201362. Epub 2012 Sep 23.
PMID:23002000
Abstract
Cascading like dominos: An efficient and highly enantioselective synthesis of 2,3,4-trisubstituted tetrahydroquinolines through cascade aza-Michael-Michael reactions was developed. Tetrahydroquinolines were obtained in excellent yields, high enantioselectivities, and good diastereoselectivities, and could be easily transformed into ring-fused tetrahydroquinolines (see scheme).
摘要
级联如多米诺骨牌
通过级联氮杂迈克尔-迈克尔反应高效、高对映选择性地合成了 2,3,4-三取代的四氢喹啉。四氢喹啉以优异的收率、高对映选择性和良好的非对映选择性得到，并且可以很容易地转化为环合的四氢喹啉（见方案）。
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