手性有机催化 C-H 键官能化的串联 1,5-氢转移/环化反应：四氢喹啉的不对称合成。
Enantioselective organocatalytic C-H bond functionalization via tandem 1,5-hydride transfer/ring closure: asymmetric synthesis of tetrahydroquinolines.
机构信息
Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Korea.
出版信息
J Am Chem Soc. 2010 Sep 1;132(34):11847-9. doi: 10.1021/ja103786c.
PMID:20701277
Abstract
The first organocatalytic enantioselective intramolecular 1,5-hydride transfer/ring closure reaction is described. This redox neutral reaction cascade allows for the efficient formation of ring-fused tetrahydroquinolines in high enantioselectivities.
摘要
本文首次报道了首例有机催化对映选择性分子内 1,5-氢转移/环化反应。这种氧化还原中性反应级联反应能够以高对映选择性有效地形成环合的四氢喹啉。
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