Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Ann Oncol. 2013 Jan;24(1):208-14. doi: 10.1093/annonc/mds247. Epub 2012 Sep 20.
Metabolic tumor volume (MTV) of (18)F-FDG PET/CT is a volumetric measurement of tumor cells with increased 18F-FDG uptake. We evaluated the prognostic value of MTV in patients with locoregionally advanced laryngeal and hypopharyngeal cancer.
We evaluated 81 patients with advanced-stage squamous cell carcinoma of the laryngohypopharynx who underwent 18F-FDG PET/CT between January 2004 and September 2009. Clinicopathologic factors and MTV were analyzed for their association with locoregional control (LRC) and overall survival (OS).
The 3-year LRC and OS for all patients were 70.9 and 78.7%, respectively, with a median follow-up of 40.4 months (range 24.5-90.1). In univariate analyses, MTV, primary site, and primary treatment strategy were associated with both LRC and OS (P<0.05). On multivariate analysis, MTV was an independent prognostic factor for both LRC [P=0.018; HR=3.141, 95% confidence interval (CI)=1.175-8.399] and OS (P=0.008; HR=3.758, 95% CI=1.415-9.982). Primary site was also a significant prognostic factor for LRC (P=0.047).
Pretreatment MTV is an independent prognostic factor in patients with locoregionally advanced squamous cell carcinoma of the larynx and hypopharynx.
（18）F-FDG PET/CT 的代谢肿瘤体积（MTV）是一种测量摄取增加的 18F-FDG 的肿瘤细胞的容积测量。我们评估了 MTV 在局部晚期喉和下咽癌患者中的预后价值。
我们评估了 81 例在 2004 年 1 月至 2009 年 9 月期间接受 18F-FDG PET/CT 的晚期声门上喉和下咽鳞状细胞癌患者。分析了临床病理因素和 MTV 与局部区域控制（LRC）和总生存（OS）的关系。
所有患者的 3 年 LRC 和 OS 分别为 70.9%和 78.7%，中位随访时间为 40.4 个月（范围 24.5-90.1）。在单因素分析中，MTV、原发部位和原发治疗策略与 LRC 和 OS 均相关（P<0.05）。在多因素分析中，MTV 是 LRC [P=0.018；HR=3.141，95%置信区间（CI）=1.175-8.399]和 OS（P=0.008；HR=3.758，95% CI=1.415-9.982）的独立预后因素。原发部位也是 LRC 的显著预后因素（P=0.047）。
局部晚期喉和下咽鳞状细胞癌患者的 MTV 是独立的预后因素。
