18F-FDG PET/CT 测量术前代谢肿瘤体积和总病变糖酵解对唾液腺癌的预后价值。
Prognostic value of preoperative metabolic tumor volume and total lesion glycolysis measured by 18F-FDG PET/CT in salivary gland carcinomas.
机构信息
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
出版信息
J Nucl Med. 2013 Jul;54(7):1032-8. doi: 10.2967/jnumed.112.116053. Epub 2013 May 13.
UNLABELLED
Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are emerging prognostic biomarkers in various human cancers. This study examined the prognostic value of these metabolic tumor parameters measured by pretreatment (18)F-FDG PET/CT in patients with salivary gland carcinomas.
METHODS
Forty-nine patients with intermediate- or high-grade salivary gland carcinomas who underwent definitive surgery with or without radiotherapy or chemoradiotherapy were evaluated preoperatively by (18)F-FDG PET/CT. Maximum standardized uptake values (SUV max), MTV, and TLG were measured for each patient. Univariate and multivariate analyses were used to identify clinicopathologic and imaging variables associated with progression-free survival (PFS) and overall survival (OS). Univariate analyses included the following variables: age, sex, pT and pN classifications, overall pTNM stage, histologic grade, resection margin, tumor lymphovascular invasion and perineural invasion, postoperative adjuvant therapy, gross total volume, SUV max, MTV, and TLG.
RESULTS
The 3-y PFS and OS rates for all study patients were 66.9% and 81.6%, respectively. The median SUV max, MTV, and TLG were 5.1 (range, 1.7-21.5), 16.2 mL (1.0-115.1 mL), and 24.4 g (2.1-224.4 g), respectively. Univariate analyses showed that there were significant correlations between pT classification, pN classification, MTV, and TLG and both PFS and OS (P < 0.05). However, SUV max was not associated with either PFS (P = 0.111) or OS (P = 0.316). Multivariate analyses revealed that MTV (P = 0.011; hazard ratio, 11.50; 95% confidence interval, 1.45-91.01) and TLG (P = 0.038; hazard ratio, 3.55; 95% confidence interval, 1.07-11.76) were independent variables for PFS.
CONCLUSION
Pretreatment values of MTV and TLG are independent prognostic factors in patients with intermediate or high-grade salivary gland carcinomas.
目的
评估术前 18F-FDG PET/CT 代谢肿瘤参数在涎腺癌患者中的预后价值。
方法
对 49 例经手术治疗（伴或不伴放化疗）的中、高级别涎腺癌患者进行术前 18F-FDG PET/CT 检查。对每位患者测量最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）。采用单因素和多因素分析确定与无进展生存期（PFS）和总生存期（OS）相关的临床病理和影像学变量。单因素分析包括以下变量：年龄、性别、pT 和 pN 分类、总 pTNM 分期、组织学分级、切缘、肿瘤脉管侵犯和神经周围侵犯、术后辅助治疗、大体肿瘤体积、SUVmax、MTV 和 TLG。
结果
所有研究患者的 3 年 PFS 和 OS 率分别为 66.9%和 81.6%。SUVmax、MTV 和 TLG 的中位数分别为 5.1（范围，1.7-21.5）、16.2ml（1.0-115.1ml）和 24.4g（2.1-224.4g）。单因素分析显示，pT 分级、pN 分级、MTV 和 TLG 与 PFS 和 OS 均有显著相关性（P<0.05）。然而，SUVmax 与 PFS（P=0.111）或 OS（P=0.316）均无相关性。多因素分析显示，MTV（P=0.011；风险比，11.50；95%置信区间，1.45-91.01）和 TLG（P=0.038；风险比，3.55；95%置信区间，1.07-11.76）是 PFS 的独立变量。
结论
术前 MTV 和 TLG 值是中、高级别涎腺癌患者的独立预后因素。
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