Desai H B, Donat J, Shokeir M H, Munoz D G
Department of Neurology, University Hospital, Saskatoon, Saskatchewan, Canada.
Neurology. 1990 Feb;40(2):378-80. doi: 10.1212/wnl.40.2.378.
Fragile X syndrome is a common cause of mental retardation. We report the clinical and pathologic features of a patient with fragile X syndrome who developed amyotrophic lateral sclerosis (ALS) at a relatively young age. Although the occurrence of these 2 diseases could be a mere coincidence, the development of ALS in this patient might be related to the chromosomal aberration of fragile X syndrome.
脆性X综合征是智力迟钝的常见病因。我们报告了一名脆性X综合征患者的临床和病理特征，该患者在相对年轻时患上了肌萎缩侧索硬化症（ALS）。尽管这两种疾病的发生可能仅仅是巧合，但该患者ALS的发展可能与脆性X综合征的染色体畸变有关。
