脆性X综合征：衰老视角
Fragile X syndrome: an aging perspective.
作者信息
Schneider Andrea, Ligsay Andrew, Hagerman Randi J
机构信息
MIND Institute, University of California at Davis Medical Center, Sacramento, California, USA.
出版信息
Dev Disabil Res Rev. 2013;18(1):68-74. doi: 10.1002/ddrr.1129.
Abstract
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation.
摘要
与FMR1基因相关的分子变异的认知和行为关联已得到相当广泛的研究，但关于脆性X谱系障碍患者长期预后的研究仍然很少。在这篇综述中，我们概述了衰老研究以及关于脆性X综合征和FMR1前突变衰老的细胞和临床表现的最新发现。
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