College of Medicine, The Ohio State University, Columbus, OH 43205, USA.
Clin Transplant. 2013 Jan-Feb;27(1):121-5. doi: 10.1111/ctr.12020. Epub 2012 Sep 24.
Lipid-laden macrophage (LLM) index could be potentially useful in assessing gastroesophageal (GE) reflux and aspiration after lung transplantation (LT) in patients with cystic fibrosis (CF).
A retrospective review of CF patients undergoing LT and/or laparoscopic Nissen fundoplication (LNF) from January 1, 2009, to December 31, 2011, was performed.
Seventeen CF patients (nine women), mean (± SD) age 27.9 ± 7.5 yr, underwent LT with mean (± SD) pre-transplant FEV(1) of 20.9 ± 5.0% predicted. Seventy percentage (12/17) of patients underwent LNF without complications within 1-2 wk of LT. After LT, but prior to antireflux surgery, there was no significant difference in the mean (± SD) baseline LLM index (154 ± 41 vs. 146 ± 51, p = NS) between patients who were to undergo LNF and patients who did not. After LNF, a significant reduction in the mean (± SD) LLM index occurred following the procedure (154 ± 41-74 ± 54, p < 0.0001) while each patient reported resolution of symptoms of GE reflux, whereas 40% (2/5) undergoing only medical treatment reported resolution of symptoms.
Significant reduction in the LLM index occurred after LNF in CF patients after LT that correlated with resolution of clinical symptoms of GE reflux.
富含脂质的巨噬细胞（LLM）指数在评估囊性纤维化（CF）患者肺移植（LT）后胃食管（GE）反流和吸入方面可能具有潜在作用。
对 2009 年 1 月 1 日至 2011 年 12 月 31 日期间接受 LT 和/或腹腔镜 Nissen 胃底折叠术（LNF）的 CF 患者进行回顾性分析。
17 例 CF 患者（9 名女性），平均（±SD）年龄 27.9±7.5 岁，平均（±SD）LT 前 FEV（1）为预计值的 20.9±5.0%。70%（12/17）的患者在 LT 后 1-2 周内接受 LNF 无并发症。LT 后，但在抗反流手术之前，接受 LNF 和未接受 LNF 的患者的基线 LLM 指数（154±41 vs. 146±51，p=NS）之间无显著差异。LNF 后，患者的 LLM 指数在手术后显著降低（154±41-74±54，p<0.0001），同时每位患者报告 GE 反流症状得到缓解，而仅接受药物治疗的 40%（2/5）患者报告症状得到缓解。
LT 后 CF 患者在接受 LNF 后 LLM 指数显著降低，与 GE 反流临床症状的缓解相关。
