Department of Surgery, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
Am J Surg. 2012 Nov;204(5):e21-6. doi: 10.1016/j.amjsurg.2012.07.019. Epub 2012 Aug 24.
Gastroesophageal reflux disease (GERD) in lung transplant patients is being increasingly investigated because of its reported association with chronic rejection. However, information concerning the characteristics of GERD in cystic fibrosis (CF) patients is scarce.
We compared esophageal pH monitoring, manometry, gastric emptying studies, and barium swallow of 10 lung transplant patients with CF with those of 78 lung transplant patients with other end-stage pulmonary diseases.
In lung transplant patients with CF, the prevalence of GERD was 90% (vs 54% controls, P = .04), of whom 70% had proximal reflux (vs 29% controls, P = .02).
Lung transplant patients with CF have a significantly higher prevalence and proximal extent of GERD than do other lung transplant recipients. These data suggest that CF patients in particular should be routinely screened for GERD after transplantation to identify those who may benefit from antireflux surgery, especially given the risks of GERD-related aspiration and chronic allograft injury.
胃食管反流病（GERD）在肺移植患者中越来越受到关注，因为它与慢性排斥反应有关。然而，有关囊性纤维化（CF）患者 GERD 特征的信息很少。
我们比较了 10 例 CF 肺移植患者与 78 例其他终末期肺部疾病肺移植患者的食管 pH 监测、测压、胃排空研究和钡餐吞咽。
CF 肺移植患者 GERD 的患病率为 90%（对照组为 54%，P =.04），其中 70%有近端反流（对照组为 29%，P =.02）。
CF 肺移植患者 GERD 的患病率和近端程度明显高于其他肺移植受者。这些数据表明，特别是 CF 患者在移植后应常规筛查 GERD，以确定那些可能受益于抗反流手术的患者，特别是考虑到 GERD 相关吸入和慢性移植物损伤的风险。
