Granström M L
Eur J Pediatr. 1979;132(4):277-87. doi: 10.1007/BF00496851.
To find out whether cytomegalovirus (CMV) infection during the first months of life influences child development, developmental assessment at the age of 2 years was performed on 116 Finnish children chosen at random in a maternity hospital and followed from birth for the occurrence of CMV infection. Two of the children had congenital infection and 39 were infected after birth but before the age of 6 months. Another five children were infected between the ages of 6 and 12 months, and 70 remained non-infected. The developmental assessment, based principally on the Denver Development Screening Test (DDST), included 7 items for gross motor skills, 6 items for fine motor skills, and 4 items for language development. Significantly more perinatally infected children (7/39) were delayed in speech, compared with the non-infected children (3/70). Furthermore, some items assessing fine motor development were passed better by the non-infected than the perinatally infected children, but the difference in total score was not significant. The performance of the two children with congenital CMV infection did not differ from that of the non-infected children.
为了查明出生后最初几个月的巨细胞病毒（CMV）感染是否会影响儿童发育，对一家妇产医院随机选取的116名芬兰儿童进行了2岁时的发育评估，这些儿童从出生起就被跟踪观察CMV感染情况。其中两名儿童有先天性感染，39名儿童在出生后但6个月前受到感染。另外5名儿童在6至12个月大时受到感染，70名儿童仍未感染。发育评估主要基于丹佛发育筛查测试（DDST），包括7项大运动技能项目、6项精细运动技能项目和4项语言发育项目。与未感染儿童（3/70）相比，围产期感染儿童（7/39）在语言方面明显更迟缓。此外，在一些评估精细运动发育的项目上，未感染儿童比围产期感染儿童完成得更好，但总分差异不显著。两名先天性CMV感染儿童的表现与未感染儿童没有差异。
