立体选择性和催化途径合成β-烯胺酮：通向嘧啶的入口。
Stereoselective and catalytic access to β-enaminones: an entry to pyrimidines.
机构信息
Institut Charles Gerhardt UMR 5253 CNRS-UM2-UM1-ENSCM, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France.
出版信息
J Org Chem. 2012 Oct 19;77(20):9205-20. doi: 10.1021/jo301675g. Epub 2012 Oct 5.
PMID:23006434
Abstract
We describe herein a highly stereoselective access to Cbz-protected β-enaminones 2 based on the NaOH catalyzed rearrangement of propargylic hydroxylamines 1. The synthetic potential of these β-enaminones is illustrated in an original synthesis of pyrimidines.
摘要
我们在此描述了一种基于 NaOH 催化的炔丙醇胺 1 重排反应，高度立体选择性地合成 Cbz 保护的β-烯胺酮 2 的方法。这些β-烯胺酮的合成潜力在嘧啶的原创合成中得到了体现。
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