DBU 催化的、导向芳构化的、β-二羰基化合物、DMF-DMA 和氰胺的区域选择性串联合成 2-氨基嘧啶。
DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from β-dicarbonyl compounds, DMF-DMA, and cyanamide.
机构信息
Department of Chemistry, Faculty of Art and Science, Bozok University, 66200, Atatürk Yolu, Yozgat, Turkey.
出版信息
Mol Divers. 2017 Nov;21(4):925-932. doi: 10.1007/s11030-017-9770-7. Epub 2017 Aug 1.
PMID:28766257
Abstract
A multicomponent domino synthesis has been developed for the preparation of 2-aminopyrimidines from β-dicarbonyl compounds, N,N-dimethylformamide dimethyl acetal, and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56-93%).
摘要
已开发出一种多组分多米诺合成方法，用于从β-二羰基化合物、N,N-二甲基甲酰胺二甲缩醛和氰胺制备 2-氨基嘧啶。该方案用于区域选择性制备 4-酰胺/酯/酮取代的 2-氨基嘧啶。十二种 2-氨基嘧啶以良好的产率（56-93%）分离出来。
Zotero 插件