Kolosov Maksim A, Orlov Valeriy D, Beloborodov Dmitriy A, Dotsenko Victor V
Department of Organic Chemistry, V.N. Karazin Kharkov National University, 61077, Kharkov, Ukraine.
Mol Divers. 2009 Feb;13(1):5-25. doi: 10.1007/s11030-008-9094-8. Epub 2008 Dec 11.
Despite prior reports of several really effective catalytic and non-catalytic approaches towards Biginelli's 3,4-dihydropyrimidin-2(1H)-ones, an overwhelming number of new catalysts for the Biginelli reaction have been recently published. Most of the catalysts are somewhat exotic, expensive, harmful and even uneffective in the absence of acidic additives. Herein we reduce the "yet-another-one-catalyst" idea to absurdity by proposing NaCl promotes the reaction that actually requires no catalyst, neither rare nor expensive.
尽管之前已有多篇报道称有几种针对Biginelli反应生成3,4-二氢嘧啶-2(1H)-酮的非常有效的催化和非催化方法，但最近仍有大量用于Biginelli反应的新型催化剂被发表。大多数催化剂有些奇特、昂贵、有害，甚至在没有酸性添加剂的情况下效果不佳。在此，我们通过提出氯化钠可促进该实际上无需催化剂（既不稀有也不昂贵）的反应，将“又一种催化剂”的想法推向了荒谬的境地。
