Departments of Neurology, Medicine, and Neurosurgery, Yale School of Medicine, New Haven, CT 06514, USA.
Cancer J. 2012 Sep-Oct;18(5):463-8. doi: 10.1097/PPO.0b013e31826c5ad5.
Invasion of cranial nerves and peripheral nerve roots, plexus, or nerves by non-Hodgkin lymphoma is denoted as neurolymphomatosis (NL). Four clinical patterns are recognized. Most commonly, NL presents as a painful polyneuropathy or polyradiculopathy, followed by cranial neuropathy, painless polyneuropathy, and peripheral mononeuropathy. Diagnosis of NL is challenging and requires integration of clinical information, imaging findings, and histopathologic examination of involved nerves or nonneural tissue and cerebrospinal fluid analysis. In the rare cases of primary NL, the diagnosis is often delayed. Successful therapy is contingent upon recognition of the disease and its exact neuroanatomic localization without delay. Treatment options include systemic chemotherapy and localized irradiation of bulky disease sites. Concomitant involvement of cerebrospinal fluid and systemic disease sites requires more complex regimens.
非霍奇金淋巴瘤侵犯颅神经和周围神经干、丛或神经被称为神经淋巴瘤病（NL）。NL 有四种临床类型。最常见的是 NL 表现为痛性多发性神经病或多神经根病，其次是颅神经病、无痛性多发性神经病和周围单神经病。NL 的诊断具有挑战性，需要整合临床信息、影像学发现以及受累神经或非神经组织和脑脊液分析的组织病理学检查。在原发性 NL 罕见的情况下，诊断往往会被延误。只有在没有延误的情况下，及时识别出疾病及其确切的神经解剖定位，才能成功治疗。治疗方案包括全身化疗和局部照射大块病变。同时累及脑脊液和全身疾病部位需要更复杂的方案。
