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剂量和镉预处理对大鼠胆汁中镉结合的影响。

Effects of dosage and cadmium pretreatment on the binding of cadmium in rat bile.

作者信息

Cikrt M, Havrdová J

出版信息

Experientia. 1979 Dec 15;35(12):1640-1. doi: 10.1007/BF01953241.

DOI:10.1007/BF01953241
PMID:230070
Abstract

The effects of dosage and of cadmium pretreatment on the binding of cadmium in rat bile were studied. With increasing dose a higher cumulative biliary excretion of Cd was observed and a higher percentage of the Cd was excreted in a low-molecular-weight form. On the other hand, after cadmium pretreatment, a decrease in the cumulative biliary excretion of cadmium was observed but a greater percentage of that excreted into the bile was bound to high molecular weight compounds.

摘要

研究了剂量及镉预处理对大鼠胆汁中镉结合情况的影响。随着剂量增加,观察到镉的胆汁累积排泄量更高,且更高比例的镉以低分子量形式排泄。另一方面,镉预处理后,观察到镉的胆汁累积排泄量减少,但排泄到胆汁中的镉有更大比例与高分子量化合物结合。

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本文引用的文献

1
Biliary excretion of 203 Hg, 64 Cu, 52 Mn, and 210 Pb in the rat.大鼠体内203汞、64铜、52锰和210铅的胆汁排泄
Br J Ind Med. 1972;29(1):74-80.
2
Excretion of cadmium through bile and intestinal wall in rats.镉通过大鼠胆汁和肠壁的排泄情况。
Br J Ind Med. 1974 Apr;31(2):134-9. doi: 10.1136/oem.31.2.134.
3
Binding of cadmium and mercury in the rat bile: studies using gel filtration.
Acta Pharmacol Toxicol (Copenh). 1974 Apr;34(4):246-53. doi: 10.1111/j.1600-0773.1974.tb03520.x.
4
Kinetics of cadmium transport in the isolated perfused rat liver.
Toxicol Appl Pharmacol. 1976 Dec;38(3):583-93. doi: 10.1016/0041-008x(76)90189-7.
5
Biliary excretion of cadmium by rats: effects of zinc, cadmium, and selenium pretreatments.大鼠镉的胆汁排泄:锌、镉和硒预处理的影响。
J Toxicol Environ Health. 1976 Sep;2(1):45-53. doi: 10.1080/15287397609529416.
6
Biliary excretion of cadmium in rat. II. The role of metallothionein in the hepatobiliary transport of cadmium.大鼠体内镉的胆汁排泄。II. 金属硫蛋白在镉的肝胆转运中的作用。
J Toxicol Environ Health. 1977 Mar;2(4):955-61. doi: 10.1080/15287397709529494.
7
Biliary excretion of cadmium in rat. I. Dose-dependent biliary excretion and the form of cadmium in the bile.大鼠体内镉的胆汁排泄。I. 胆汁中镉的剂量依赖性排泄及镉的存在形式
J Toxicol Environ Health. 1977 Mar;2(4):945-54. doi: 10.1080/15287397709529493.