注射甲状腺素的年轻和老年大鼠下丘脑-垂体-肾上腺轴的调控
Control of the hypothalamus-pituitary-adrenal axis in young and older rats injected with thyroxine.
作者信息
Meserve L A
出版信息
Experientia. 1979 Dec 15;35(12):1675-6. doi: 10.1007/BF01953266.
PMID:230073
Abstract
Administration of T4 on alternate weeks for 30 weeks at a dosage which does not alter body weight depresses basal serum corticosterone levels in older rats (575 days), but not in young animals (260 days). Similar serum corticosterone response to HPA axis stimulation occurs regardless of age or T4 injection.
摘要
在不改变体重的剂量下，对老年大鼠（575天）每隔一周给予甲状腺素（T4），持续30周，可降低其基础血清皮质酮水平，但对年轻动物（260天）则无此作用。无论年龄或是否注射T4，对下丘脑-垂体-肾上腺（HPA）轴刺激的血清皮质酮反应相似。
Zotero 插件