非酶酰基转移催化剂介导的内消旋二醇的去对称化。
Desymmetrisation of meso-diols mediated by non-enzymatic acyl transfer catalysts.
机构信息
University of Geneva, Department of Organic Chemistry, Switzerland.
出版信息
Chem Soc Rev. 2012 Dec 7;41(23):7803-31. doi: 10.1039/c2cs35049a.
PMID:23007376
Abstract
Complementary to enzymatic methods, catalytic enantioselective desymmetrisation of meso-diols (EDMD) by small molecule catalysts has emerged as a powerful tool that provides highly enantioenriched materials of considerable value in organic synthesis. This review traces the evolution of easily accessible catalysts used in the EDMD and compares their performance with the existing enzymatic methods.
摘要
与酶法相辅相成的是，小分子催化剂的手性催化对映选择性去对称化（EDMD）已成为一种强大的工具，为有机合成提供了具有重要价值的高对映体过量的材料。本文综述了 EDMD 中使用的易得催化剂的发展，并比较了它们与现有酶法的性能。
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