Todd J R, West B C, McDonald J C
Department of Medicine, Louisiana State University School of Medicine, Shreveport.
Rev Infect Dis. 1990 Jan-Feb;12(1):63-74. doi: 10.1093/clinids/12.1.63.
We examined the relationship of human leukocyte antigen (HLA) phenotype to leprosy in six sporadic cases in northern Louisiana and in the world literature through pooling of the results of several studies. We found that HLA antigens DR2 and DQwl were associated with leprosy in the six cases in northern Louisiana (relative risks, 4.57 for DR2 and 4.53 for DQwl), but the results are not statistically significant. We pooled the Louisiana study and other population studies of HLA and leprosy. The results of the pooling show DR2 and DQwl to be associated with leprosy (relative risks, 2.65 for DR2 and 2.73 for DQwl), and these associations are highly statistically significant (P less than 1 x 10(-8) for DR2 and P = 3.6 x 10(-8) for DQwl). Further, we pooled studies of lepromatous leprosy patients vs. controls and studies of tuberculoid leprosy patients vs. controls and found that DR2 and DQwl are associated with both the lepromatous and the tuberculoid forms of leprosy and that these associations are statistically significant. We consider the associations of DR2 and DQwl in these population studies to be evidence for an HLA-associated genetic influence on susceptibility to leprosy.
我们通过汇总多项研究结果，研究了路易斯安那州北部6例散发性麻风病例以及世界文献中人类白细胞抗原（HLA）表型与麻风病的关系。我们发现，在路易斯安那州北部的6例病例中，HLA抗原DR2和DQw1与麻风病相关（相对风险，DR2为4.57，DQw1为4.53），但结果无统计学意义。我们汇总了路易斯安那州的研究以及其他关于HLA与麻风病的人群研究。汇总结果显示DR2和DQw1与麻风病相关（相对风险，DR2为2.65，DQw1为2.73），且这些关联具有高度统计学意义（DR2的P值小于1×10⁻⁸，DQw1的P值 = 3.6×10⁻⁸）。此外，我们汇总了瘤型麻风病患者与对照的研究以及结核样型麻风病患者与对照的研究，发现DR2和DQw1与瘤型和结核样型麻风病均相关，且这些关联具有统计学意义。我们认为在这些人群研究中DR2和DQw1的关联是HLA相关基因影响麻风病易感性的证据。
