Banerjee Jaideep, Sen Chandan K
Department of Surgery, Ohio State University Medical Center, Columbus, OH, USA.
Methods Mol Biol. 2013;936:343-56. doi: 10.1007/978-1-62703-083-0_26.
MicroRNAs (miRNAs) are small noncoding RNA molecules ∼22 nucleotides in length that can post-transcriptionally repress gene expression. MiRNAs bind to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. Chronic wounds represent a major health burden and drain on resources and developing more effective treatments is therefore a necessity. Increase in the understanding of the regulation of chronic wound biology is therefore required to develop newer therapies. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.
微小RNA(miRNA)是长度约为22个核苷酸的小型非编码RNA分子,可在转录后抑制基因表达。miRNA与其靶信使RNA(mRNA)结合,导致mRNA降解或翻译抑制。最近研究表明,miRNA在皮肤发育中起关键作用,并与各种皮肤病理、癌症和伤口愈合相关。慢性伤口是一项重大的健康负担,消耗大量资源,因此开发更有效的治疗方法很有必要。因此,需要加强对慢性伤口生物学调控的理解,以开发新的治疗方法。本综述重点关注miRNA在皮肤生物学中的作用、miRNA调节的各种方法以及在治疗皮肤疾病和伤口愈合方面的治疗机会。