Department of Psychiatry, Goethe University, Frankfurt am Main, Germany.
Nat Rev Neurol. 2012 Nov 5;8(11):598-600. doi: 10.1038/nrneurol.2012.202. Epub 2012 Sep 25.
Whether dominantly inherited variants of Alzheimer disease (AD) and 'sporadic' forms exhibit similar pathophysiological and biomarker signatures remains unresolved. A landmark study has proposed a biomarker progression model of dominantly inherited AD, but a complex systems biology and physiology approach is required to translate these findings to sporadic disease.
显性遗传阿尔茨海默病（AD）和“散发性”形式的变异是否表现出相似的病理生理和生物标志物特征仍未解决。一项具有里程碑意义的研究提出了一种显性遗传 AD 的生物标志物进展模型，但需要采用复杂的系统生物学和生理学方法将这些发现转化为散发性疾病。
