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[重症肌无力患者硫唑嘌呤治疗期间出现的发疹性黑素细胞痣]

[Eruptive melanocytic nevi during azathioprine therapy in myasthenia gravis].

作者信息

Braun S A, Helbig D, Frank J, Hanneken S

机构信息

Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

出版信息

Hautarzt. 2012 Oct;63(10):756-9. doi: 10.1007/s00105-012-2440-x.

Abstract

While being treated with azathioprine and dexamethasone, a 21-year old man with myasthenia gravis suddenly developed rapidly progressing brown macules, predominantly on the trunk, palms and soles. We made a diagnosis of eruptive melanocytic nevi (EMN). This rare entity can appear after blistering skin diseases, in immunocompromised patients, and, in particular, during immunosuppressive therapy for autoimmune diseases. Since therapeutic regimens including azathioprine have been frequently reported in association with EMN, we recommended to our patient a treatment switch to mycophenolic acid to prevent the development of more nevi.

摘要

一名21岁的重症肌无力男性患者在接受硫唑嘌呤和地塞米松治疗时,突然在躯干、手掌和脚底迅速出现进展性褐色斑疹。我们诊断为发疹性黑素细胞痣(EMN)。这种罕见的病症可出现在水疱性皮肤病后、免疫功能低下的患者中,尤其是在自身免疫性疾病的免疫抑制治疗期间。由于包括硫唑嘌呤在内的治疗方案经常被报道与EMN有关,我们建议患者改用霉酚酸治疗,以防止出现更多痣。

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