Woodhouse Justin, Maytin Edward V
Cleveland Clinic, Cleveland, Ohio 44195, USA.
J Am Acad Dermatol. 2005 May;52(5 Suppl 1):S96-S100. doi: 10.1016/j.jaad.2004.08.009.
The sudden eruption of atypical and benign melanocytic nevi has been associated with a number of disease states and primary skin conditions. Most case reports and series of patients have linked eruptive nevi with blistering skin disease or immunosuppression. Subsets of patients in the immunosuppressed category have remarkably increased numbers of nevi on the palms and soles. We describe a case of multiple eruptive nevi of the palms and soles in association with immunosuppression, and the potential underlying mechanisms promoting such nevogenesis are explored. Although both the absolute number of nevi and presence of dysplastic nevi have been correlated with an increased relative risk of melanoma, actual risk of melanoma in patients with eruptive nevi is unknown.
非典型性和良性黑素细胞痣的突然出现与多种疾病状态和原发性皮肤疾病相关。大多数病例报告及系列患者研究已将发疹性痣与水疱性皮肤病或免疫抑制联系起来。免疫抑制类别中的部分患者手掌和脚底的痣数量显著增加。我们描述了一例与免疫抑制相关的手掌和脚底多发性发疹性痣病例，并探讨了促进这种痣形成的潜在机制。虽然痣的绝对数量和发育异常痣的存在都与黑色素瘤相对风险增加相关，但发疹性痣患者患黑色素瘤的实际风险尚不清楚。
