Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
Gene. 2013 Jan 1;512(1):76-81. doi: 10.1016/j.gene.2012.09.034. Epub 2012 Sep 23.
Variants of transcription factor 7-like 2 (TCF7L2) gene have been reported to be associated with type 2 diabetes mellitus (T2DM), but the available data on this relationship are inconsistent in Han Chinese populations. A meta-analysis was performed to quantitatively analyze the association of TCF7L2 gene polymorphisms with T2DM using previous case-control studies in Chinese Han populations. Several electronic databases were searched for relevant articles up to May 2012. After data collection and gene loci selection, a meta-analysis was performed to assess heterogeneity, combine results and evaluate variations. Publication bias was examined by the Egger's linear regression test. Hardy-Weinberg equilibrium (HWE) test and by omitting one study at a time were employed for the sensitivity analysis. Eighteen studies from sixteen eligible papers were included in the meta-analysis. Ten eligible studies were analyzed for rs7903146, and eight were analyzed for rs290487. We found that the rs7903146 T allele was associated with an increased risk for T2DM under a dominant model, a co-dominant model and an allele contrast model, with an OR of 1.54 (1.32, 1.79), an OR of 1.53 (1.31, 1.79) and an OR of 1.52 (1.31, 1.76), respectively. The rs290487 C allele showed no significant overall association with T2DM, yielding ORs of 1.08 (0.88, 1.32) under a dominant model, with strong evidence of heterogeneity. Similar results were also obtained in other genetic models. Sensitivity analysis confirmed the reliability and stability of this meta-analysis. The accumulated evidence suggested that the rs7903146 T allele was associated with an increased risk for T2DM, but the rs290487 C allele is not associated with T2DM in the Chinese Han population. More well-designed large studies are required for the validation of this association.
TCF7L2 基因转录因子 7 样 2 （TCF7L2）的变体已被报道与 2 型糖尿病（T2DM）相关，但在汉族人群中，这一关系的可用数据不一致。采用病例对照研究的荟萃分析方法，对汉族人群 TCF7L2 基因多态性与 T2DM 的相关性进行了定量分析。截至 2012 年 5 月，检索了多个电子数据库以获取相关文章。在数据收集和基因座选择后，进行了荟萃分析以评估异质性、合并结果和评估变异。通过 Egger 的线性回归检验、Hardy-Weinberg 平衡（HWE）检验和每次删除一项研究进行敏感性分析来检测发表偏倚。纳入了 16 篇合格论文中的 18 项研究进行荟萃分析。10 项合格研究分析 rs7903146，8 项分析 rs290487。结果发现，rs7903146T 等位基因在显性模型、共显性模型和等位基因对照模型下与 T2DM 风险增加相关，OR 为 1.54（1.32，1.79）、OR 为 1.53（1.31，1.79）和 OR 为 1.52（1.31，1.76）。rs290487C 等位基因在显性模型下与 T2DM 无显著总体相关性，OR 为 1.08（0.88，1.32），且存在显著异质性。其他遗传模型也得到了类似的结果。敏感性分析证实了该荟萃分析的可靠性和稳定性。累积证据表明，rs7903146T 等位基因与 T2DM 风险增加相关，但 rs290487C 等位基因与汉族人群的 T2DM 无关。需要更多设计良好的大型研究来验证这种关联。
